Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia

• Main Authors: Wataru Nemoto (Author), Kotaro Yamada (Author), Yoshiki Ogata (Author), Osamu Nakagawasai (Author), Katsuhito Onodera (Author), Hidetomo Sakurai (Author), Koichi Tan-No (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day...