Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia
We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2016-08-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_8b446f64b5de41d3814eac1e0173c5c4 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Wataru Nemoto |e author |
| 700 | 1 | 0 | |a Kotaro Yamada |e author |
| 700 | 1 | 0 | |a Yoshiki Ogata |e author |
| 700 | 1 | 0 | |a Osamu Nakagawasai |e author |
| 700 | 1 | 0 | |a Katsuhito Onodera |e author |
| 700 | 1 | 0 | |a Hidetomo Sakurai |e author |
| 700 | 1 | 0 | |a Koichi Tan-No |e author |
| 245 | 0 | 0 | |a Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia |
| 260 | |b Elsevier, |c 2016-08-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2016.07.009 | ||
| 520 | |a We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day 10 after formalin injection. On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase in c-Fos-immunoreactive dorsal lumbar neurons were attenuated by the repeated administration of CS. These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord. | ||
| 546 | |a EN | ||
| 690 | |a Chondroitin sulfate | ||
| 690 | |a Tactile allodynia | ||
| 690 | |a Spinal cord | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 131, Iss 4, Pp 275-278 (2016) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861316300913 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8b446f64b5de41d3814eac1e0173c5c4 |z Connect to this object online. |