Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

• Main Authors: Chisayo Kozuka (Author), Chigusa Shimizu-Okabe (Author), Chitoshi Takayama (Author), Kaku Nakano (Author), Hidetaka Morinaga (Author), Ayano Kinjo (Author), Kotaro Fukuda (Author), Asuka Kamei (Author), Akihito Yasuoka (Author), Takashi Kondo (Author), Keiko Abe (Author), Kensuke Egashira (Author), Hiroaki Masuzaki (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our previous works demonstrated that brown rice-specific bioactive substance, γ-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)-induced obese diabetic...