Pan-Cancer Analysis Shows <i>TP53</i> Mutations Modulate the Association of NOX4 with Genetic Programs of Cancer Progression and Clinical Outcome

• Main Authors: Wei Feng Ma (Author), Howard E. Boudreau (Author), Thomas L. Leto (Author)
• 格式: 图书
• 出版: MDPI AG, 2021-02-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Previously, we have shown TGF-β-induced NOX4 expression is involved in the epithelial-to-mesenchymal transition (EMT), a process critical for cancer metastasis, and that wild-type (WT) and mutant (Mut) p53 have divergent effects on TGF-β induction of NOX4: WT-p53 suppresses whereas Mut-p53 augments...