Type 1 diabetes prevention clinical trial simulator: Case reports of model‐informed drug development tool

• Main Authors: Juan Francisco Morales (Author), Marian Klose (Author), Yannick Hoffert (Author), Jagdeep T. Podichetty (Author), Jackson Burton (Author), Stephan Schmidt (Author), Klaus Romero (Author), Inish O'Doherty (Author), Frank Martin (Author), Martha Campbell‐Thompson (Author), Michael J. Haller (Author), Mark A. Atkinson (Author), Sarah Kim (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinical trials seeking to delay or prevent the onset of type 1 diabetes (T1D) face a series of pragmatic challenges. Despite more than 100 years since the discovery of insulin, teplizumab remains the only FDA‐approved therapy to delay progression from Stage 2 to Stage 3 T1D. To increase th...