Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

• Main Authors: Michael R. Dyson (Author), Edward Masters (Author), Deividas Pazeraitis (Author), Rajika L. Perera (Author), Johanna L. Syrjanen (Author), Sachin Surade (Author), Nels Thorsteinson (Author), Kothai Parthiban (Author), Philip C. Jones (Author), Maheen Sattar (Author), Gordana Wozniak-Knopp (Author), Florian Rueker (Author), Rachael Leah (Author), John McCafferty (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The early phase of protein drug development has traditionally focused on target binding properties leading to a desired mode of therapeutic action. As more protein therapeutics pass through the development pipeline; however, it is clear that non-optimal biophysical properties can emerge, particularl...