Arrest of mouse preterm labor until term delivery by combination therapy with atosiban and mundulone, a natural product with tocolytic efficacy

• Main Authors: Shajila Siricilla (Author), Christopher J. Hansen (Author), Jackson H. Rogers (Author), Debasmita De (Author), Carolyn L. Simpson (Author), Alex G. Waterson (Author), Gary A. Sulikowski (Author), Stacey L. Crockett (Author), Naoko Boatwright (Author), Jeff Reese (Author), Bibhash C. Paria (Author), J. Newton (Author), Jennifer L. Herington (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a lack of FDA-approved tocolytics for the management of preterm labor (PL). In prior drug discovery efforts, we identified mundulone and mundulone acetate (MA) as inhibitors of in vitro intracellular Ca2+-regulated myometrial contractility. In this study, we probed the tocolytic potential o...