Single Nucleotide Variants as Proxies for HLA-A*31:01 in Native American Populations

• Auteurs principaux: Vanessa Câmara Fernandes (Auteur), Marco Antônio M. Pretti (Auteur), Luiza Tamie Tsuneto (Auteur), Maria Luiza Petzl-Erler (Auteur), Guilherme Suarez-Kurtz (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Carbamazepine triggers dermatologic hypersensitivity reactions, associated with specific human leukocyte antigens (HLAs), especially HLA-B*15:02 and HLA-A*31:01. Previous efforts to identify single nucleotide variants (SNVs) with high predictive value as HLA proxies, revealed that rs1061235 and rs17...