Spontaneous shaker rat mutant - a new model for X-linked tremor/ataxia

• Main Authors: Karla P. Figueroa (Author), Sharan Paul (Author), Tito Calì (Author), Raffaele Lopreiato (Author), Sukanya Karan (Author), Martina Frizzarin (Author), Darren Ames (Author), Ginevra Zanni (Author), Marisa Brini (Author), Warunee Dansithong (Author), Brett Milash (Author), Daniel R. Scoles (Author), Ernesto Carafoli (Author), Stefan M. Pulst (Author)
• Format: Book
• Published: The Company of Biologists, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The shaker rat is an X-linked recessive spontaneous model of progressive Purkinje cell (PC) degeneration exhibiting a shaking ataxia and wide stance. Generation of Wistar Furth (WF)/Brown Norwegian (BN) F1 hybrids and genetic mapping of F2 sib-sib offspring using polymorphic markers narrowed the can...