The pharmacology of TD-8954, a potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties

• Main Authors: David T Beattie (Author), Scott R Armstrong (Author), Ross G Vickery (Author), Pam eTsuruda (Author), Christina B Campbell (Author), Carrie eRichardson (Author), Julia eMcCullough (Author), Oranee eDaniels (Author), Kathryn eKersey (Author), Yu-Ping eLi (Author), Karl HS Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT4 receptor agonist. TD-8954 had high affinity (pKi = 9.4) for human recombinant 5-HT4(c) (h5-HT4(c)) receptors, and selectivity (> 2,000-fold) over all other 5-HT receptors and non-5-HT...