The pharmacology of TD-8954, a potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties

• 主要な著者: David T Beattie (著者), Scott R Armstrong (著者), Ross G Vickery (著者), Pam eTsuruda (著者), Christina B Campbell (著者), Carrie eRichardson (著者), Julia eMcCullough (著者), Oranee eDaniels (著者), Kathryn eKersey (著者), Yu-Ping eLi (著者), Karl HS Kim (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2011-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT4 receptor agonist. TD-8954 had high affinity (pKi = 9.4) for human recombinant 5-HT4(c) (h5-HT4(c)) receptors, and selectivity (> 2,000-fold) over all other 5-HT receptors and non-5-HT...