The pharmacology of TD-8954, a potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties
This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT4 receptor agonist. TD-8954 had high affinity (pKi = 9.4) for human recombinant 5-HT4(c) (h5-HT4(c)) receptors, and selectivity (> 2,000-fold) over all other 5-HT receptors and non-5-HT...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2011-05-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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