LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification

• Main Authors: Takashi Mochizuki (Author), Kaito Shibata (Author), Takafumi Naito (Author), Kumiko Shimoyama (Author), Noriyoshi Ogawa (Author), Masato Maekawa (Author), Junichi Kawakami (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry (LC-MS/MS) method has not been widely applied in clinical settings because of its time-consuming and costly sample pretreatments. The present study aimed to develop a validated LC-MS/MS method for detecting se...