TGR5 potentiates GLP-1 secretion and cause pancreatic islet regeneration in response to Tithonia diversifolia saponin-rich extract in diabetic model mice

• Autori principali: Oluwamodupe Cecilia Ejelonu, PhD (Biochemistry) (Autore), Olusola Olalekan Elekofehinti (Autore), Isaac Gbadura Adanlawo (Autore), Rakesh Kundu (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background: Activation of Takeda G-protein bile acid receptor 5 (TGR5) secretes glucagon-like peptide-1 (GLP1) downstream insulin release. Saponin which has been indicated as the antidiabetic principle in plant shared similar steroidal scaffold with cholic acid (primary agonist of TGR5), hence antid...