CLIPB4 Is a Central Node in the Protease Network that Regulates Humoral Immunity in Anopheles gambiae Mosquitoes

• Main Authors: Xiufeng Zhang (Author), Shasha Zhang (Author), Junyao Kuang (Author), Kathleen A. Sellens (Author), Bianca Morejon (Author), Sally A. Saab (Author), Miao Li (Author), Eve C. Metto (Author), Chunju An (Author), Christopher T. Culbertson (Author), Mike A. Osta (Author), Caterina Scoglio (Author), Kristin Michel (Author)
• Format: Book
• Published: Karger Publishers, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insect humoral immune responses are regulated in part by protease cascades, whose components circulate as zymogens in the hemolymph. In mosquitoes, these cascades consist of clip-domain serine proteases (cSPs) and/or their non-catalytic homologs, which form a complex network, whose molecular make-up...