Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

• Glavni autori: Leon Cyranka (Autor), Ida Mariegaard (Autor), Mikkel-Ole Skjødt (Autor), Rafael Bayarri-Olmos (Autor), Tom Eirik Mollnes (Autor), Peter Garred (Autor), Anne Rosbjerg (Autor)
• Format: Knjiga
• Izdano: Karger Publishers, 2023-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer. We describe the generation and selection of a potent antagonistic C5aR...