Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

• Main Authors: Leon Cyranka (Author), Ida Mariegaard (Author), Mikkel-Ole Skjødt (Author), Rafael Bayarri-Olmos (Author), Tom Eirik Mollnes (Author), Peter Garred (Author), Anne Rosbjerg (Author)
• Format: Book
• Published: Karger Publishers, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer. We describe the generation and selection of a potent antagonistic C5aR...