Cyclosporin A enhances neural precursor cell survival in mice through a calcineurin-independent pathway

• Main Authors: Nadia Sachewsky (Author), Jessica Hunt (Author), Michael J. Cooke (Author), Ashkan Azimi (Author), Taraneh Zarin (Author), Carween Miu (Author), Molly S. Shoichet (Author), Cindi M. Morshead (Author)
• Format: Book
• Published: The Company of Biologists, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclosporin A (CsA) has direct effects on neural stem and progenitor cells (together termed neural precursor cells; NPCs) in the adult central nervous system. Administration of CsA in vitro or in vivo promotes the survival of NPCs and expands the pools of NPCs in mice. Moreover, CsA administration i...