Innate activation of human neutrophils and neutrophil-like cells by the pro-inflammatory bacterial metabolite ADP-heptose and Helicobacter pylori

• Main Authors: Larissa Faass (Author), Martina Hauke (Author), Saskia C. Stein (Author), Christine Josenhans (Author)
• Formato: Livro
• Publicado em: Elsevier, 2023-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Lipopolysaccharide inner core heptose metabolites, including ADP-heptose, play a substantial role in the activation of cell-autonomous innate immune responses in eukaryotic cells, via the ALPK1-TIFA signaling pathway, as demonstrated for various pathogenic bacteria. The important role of LPS heptose...