Influence of novel CYP2C‐haplotype on proton pump inhibitor pharmacokinetics in children

• Main Authors: Kathryn E. Kyler (Author), Andrea Gaedigk (Author), Susan Abdel‐Rahman (Author), Vincent S. Staggs (Author), Robin E. Pearce (Author), Paul Toren (Author), J. Steven Leeder (Author), Valentina Shakhnovich (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In this brief report, we provide an analysis of the influence of a novel CYP2C haplotype (CYP2C:TG) on proton pump inhibitor (PPI) pharmacokinetics (PK) in children. The CYP2C:TG haplotype has been proposed to be associated with increased CYP2C19 activity. We sought to determine if this CYP...