Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells

• Main Authors: Mark C. Bagley (Author), Mohammed Baashen (Author), Irina Chuckowree (Author), Jessica E. Dwyer (Author), David Kipling (Author), Terence Davis (Author)
• Format: Book
• Published: MDPI AG, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline with a 3-pyridinylboronic acid, the coupling...