Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice

• Main Authors: Cheng Li (Author), Jing-Jing Xu (Author), Hong-Tao Hu (Author), Chao-Yi Shi (Author), Chuan-Jin Yu (Author), Jian-Zhong Sheng (Author), Yan-Ting Wu (Author), He-Feng Huang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Amylin was found to regulate glucose and lipid metabolism by acting on the arcuate nucleus of the hypothalamus (ARC). Maternal high-fat diet (HFD) induces sex-specific metabolic diseases mediated by the ARC in offspring. This study was performed to explore 1) the effect of maternal HFD-in...