Structure-Activity Relationship of PAD4 Inhibitors and Their Role in Tumor Immunotherapy

• Main Authors: Yijiang Jia (Author), Renbo Jia (Author), Ayijiang Taledaohan (Author), Yanming Wang (Author), Yuji Wang (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2024-02-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Protein arginine deiminase 4 (PAD4) plays an important role in cancer progression by participating in gene regulation, protein modification, and neutrophil extracellular trap (NET) formation. Many reversible and irreversible PAD4 inhibitors have been reported recently. In this review, we summarize t...