Saporin Toxin Delivered by Engineered Colloidal Nanoparticles Is Strongly Effective against Cancer Cells

• Main Authors: Lucia Salvioni (Author), Filippo Testa (Author), Linda Barbieri (Author), Marco Giustra (Author), Jessica Armida Bertolini (Author), Giulia Tomaino (Author), Paolo Tortora (Author), Davide Prosperi (Author), Miriam Colombo (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribosome-inactivating proteins, including Saporin toxin, have found application in the search for innovative alternative cancer therapies to conventional chemo- and radiotherapy. Saporin's main mechanism of action involves the inhibition of cytoplasmic protein synthesis. Its strong theoretical...