Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines

• Main Authors: Ali Abdollahi (Author), Davoud Asgari (Author), Simin Sharifi (Author), Soodabeh Davaran (Author), Saeed Ghasemi (Author), Javid Shahbazi Mojarrad (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2013-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Farnesyltransferase (FTase) is a zinc-dependent enzyme that adds a farnesyl group to the Ras proteins. L778, 123 is a potent peptidomimetic imidazole-containing FTase inhibitor. Methods: L778123 was synthesized according to known methods and evaluated alone and in combination with doxorubic...