Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling

• Main Authors: Venkata K. Yellepeddi (Author), Kaustubh Parashar (Author), Spencer M. Dean (Author), Kevin M. Watt (Author), Jonathan E. Constance (Author), Olga J. Baker (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sjögren's syndrome (SS) is an autoimmune disease with no effective treatment options. Resolvin D1 (RvD1) belongs to a class of lipid‐based specialized pro‐resolving mediators that showed efficacy in preclinical models of SS. We developed a physiologically‐based pharmacokinetic (PBPK) model of R...