Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay

• Main Authors: Kousuke Mouri (Author), Hannah B. Dewey (Author), Rodrigo Castro (Author), Daniel Berenzy (Author), Susan Kales (Author), Ryan Tewhey (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Both upregulation and downregulation by cis-regulatory elements help modulate precise gene expression. However, our understanding of repressive elements is far more limited than activating elements. To address this gap, we characterized RE1, a group of transcriptional silencers bound by RES...