Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro

• Main Authors: Antoine Guyon (Author), Joël Rousseau (Author), Francis-Gabriel Bégin (Author), Tom Bertin (Author), Gabriel Lamothe (Author), Jacques P. Tremblay (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The amyloid precursor protein (APP) is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer's disease. Genomic analysis of an Icelandic population that did not show symptoms...