Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro
The amyloid precursor protein (APP) is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer's disease. Genomic analysis of an Icelandic population that did not show symptoms...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Elsevier,
2021-06-01T00:00:00Z.
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