Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism

• Main Authors: Bradley N. Spatola (Author), Alana G. Lerner (Author), Clifford Wong (Author), Tracy dela Cruz (Author), Megan Welch (Author), Wanchi Fung (Author), Maria Kovalenko (Author), Karolina Losenkova (Author), Gennady G. Yegutkin (Author), Courtney Beers (Author), John Corbin (Author), Vanessa B. Soros (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The extracellular ATP/adenosine axis in the tumor microenvironment (TME) has emerged as an important immune-regulatory pathway. Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), otherwise known as CD39, is highly expressed in the TME, both on infiltrating immune cells and tumor cells across a...