Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis

• Main Authors: Yixian Li (Author), Peng Yang (Author), Ran Meng (Author), Shuting Xu (Author), Lingling Zhou (Author), Kang Qian (Author), Pengzhen Wang (Author), Yunlong Cheng (Author), Dongyu Sheng (Author), Minjun Xu (Author), Tianying Wang (Author), Jing Wu (Author), Jinxu Cao (Author), Qizhi Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer's disease (AD) collectively culminate in neuronal deterioration. In the context of AD, autophagy dysfunction, a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/mi...