Honokiol attenuate the arsenic trioxide‐induced cardiotoxicity by reducing the myocardial apoptosis

• Main Authors: An‐Liang Huang (Author), Fan Yang (Author), Ping Cheng (Author), Dian‐ying Liao (Author), Li Zhou (Author), Xing‐Li Ji (Author), Dou‐Dou Peng (Author), Li Zhang (Author), Ting‐Ting Cheng (Author), Li Ma (Author), Xian‐Gen Xia (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Despite advantages of arsenic trioxide (ATO) in oncological practice, its clinical applications have been hampered by severe cardiotoxicity. The general mechanism of ATO‐induced cardiotoxicity has been attributed to its damage to mitochondria, resulting in cardiac remodeling. Honokiol (HKL)...