Quality by design for mRNA platform purification based on continuous oligo-dT chromatography

Quality by design for mRNA platform purification based on continuous oligo-dT chromatography

Oligo-deoxythymidine (oligo-dT) ligand-based affinity chromatography is a robust method for purifying mRNA drug substances within the manufacturing process of mRNA-based products, including vaccines and therapeutics. However, the conventional batch mode of operation for oligo-dT chromatography has c...

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Main Authors: Jixin Qu (Author), Adithya Nair (Author), George W. Muir (Author), Kate A. Loveday (Author), Zidi Yang (Author), Ehsan Nourafkan (Author), Emma N. Welbourne (Author), Mabrouka Maamra (Author), Mark J. Dickman (Author), Zoltán Kis (Author)
Format: Book
Published: Elsevier, 2024-12-01T00:00:00Z.
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