Histamine Produced by Gram-Negative Bacteria Impairs Neutrophil's Antimicrobial Response by Engaging the Histamine 2 Receptor

• Main Authors: Karim Dib (Author), Amal El Banna (Author), Clara Radulescu (Author), Guillermo Lopez Campos (Author), Gerard Sheehan (Author), Kevin Kavanagh (Author)
• Format: Book
• Published: Karger Publishers, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We found that histamine (10−9 M) did not have any effect on the in vitro capture of Escherichia coli by neutrophils but accelerated its intracellular killing. In contrast, histamine (10−6 M) delayed the capture of Escherichia coli by neutrophils and reduced the amounts of pHrodo zymosan particles in...