In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics

• Hlavní autoři: Jose V. Carratalá (Autor), Eric Brouillette (Autor), Naroa Serna (Autor), Alejandro Sánchez-Chardi (Autor), Julieta M. Sánchez (Autor), Antonio Villaverde (Autor), Anna Arís (Autor), Elena Garcia-Fruitós (Autor), Neus Ferrer-Miralles (Autor), François Malouin (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2020-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to conventional antibiotics. In this work, the antimicrobial peptide, GWH1, was N-terminally fused to t...