In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics

• Main Authors: Jose V. Carratalá (Author), Eric Brouillette (Author), Naroa Serna (Author), Alejandro Sánchez-Chardi (Author), Julieta M. Sánchez (Author), Antonio Villaverde (Author), Anna Arís (Author), Elena Garcia-Fruitós (Author), Neus Ferrer-Miralles (Author), François Malouin (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to conventional antibiotics. In this work, the antimicrobial peptide, GWH1, was N-terminally fused to t...