HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis

• Main Authors: Alex Pezzotta (Author), Ilaria Gentile (Author), Donatella Genovese (Author), Maria Grazia Totaro (Author), Cristina Battaglia (Author), Anskar Yu-Hung Leung (Author), Monica Fumagalli (Author), Matteo Parma (Author), Gianni Cazzaniga (Author), Grazia Fazio (Author), Myriam Alcalay (Author), Anna Marozzi (Author), Anna Pistocchi (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant activation of the Hh pathway promotes cell proliferation and multi-drug resistance (MDR) in several cancers, including Acute Myeloid Leukemia (AML). Notably, only one Hh inhibitor, glasdegib, has been approved for AML treatment, and most patients eventually relapse, highlighting the urgent...