Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model

• Main Authors: Cristina Martínez-García (Author), Adriana Izquierdo (Author), Vidya Velagapudi (Author), Yurena Vivas (Author), Ismael Velasco (Author), Mark Campbell (Author), Keith Burling (Author), Fernando Cava (Author), Manuel Ros (Author), Matej Orešič (Author), Antonio Vidal-Puig (Author), Gema Medina-Gomez (Author)
• Format: Book
• Published: The Company of Biologists, 2012-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Individuals with metabolic syndrome are at high risk of developing chronic kidney disease (CKD) through unclear pathogenic mechanisms. Obesity and diabetes are known to induce glucolipotoxic effects in metabolically relevant organs. However, the pathogenic role of glucolipotoxicity in the ae...