Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages

• Main Authors: R. Clive Landis (Author), Pandelis Philippidis (Author), Jan Domin (Author), Joseph J. Boyle (Author), Dorian O. Haskard (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intraplaque hemorrhage causes adaptive remodelling of macrophages towards a protective phenotype specialized towards handling iron and lipid overload, denoted Mhem. The Mhem phenotype expresses elevated levels of hemoglobin (Hb) scavenger receptor, CD163, capable of endocytosing pro-oxidant free Hb...