Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway

• Main Authors: Pan Zhang (Author), Xing Lai (Author), Mao-Hua Zhu (Author), Mei Long (Author), Xue-Liang Liu (Author), Zi-Xiang Wang (Author), Yifan Zhang (Author), Run-Jie Guo (Author), Jing Dong (Author), Qin Lu (Author), Peng Sun (Author), Chao Fang (Author), Mei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum, has been revealed to have a variety of pharmacological activities. However, whether SSA can inhibit angiogenesis, a key step in solid tumor progression, remains unknown. In this study, we demonstrated that SSA could po...