Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State

• Main Authors: Zhengyang Bao (Author), Lihua Li (Author), Yue Geng (Author), Jinchuan Yan (Author), Zhiyin Dai (Author), Chen Shao (Author), Zhen Sun (Author), Lele Jing (Author), Qiwen Pang (Author), Lili Zhang (Author), Xiaodong Wang (Author), Zhongqun Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Advanced glycation end products play an important role in diabetic atherosclerosis. The effects of advanced glycation end products (AGEs) on vascular smooth muscle cell- (VSMC-) derived foam cell formation and phenotypic transformation are unknown. Methods. Serological and histological s...