Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus

• Main Authors: Laure Delavallée (Author), Navrita Mathiah (Author), Lauriane Cabon (Author), Aurélien Mazeraud (Author), Marie-Noelle Br (Author), Leticia K. Lerner (Author), Mariana Tannoury (Author), Alexandre Prola (Author), Raquel Moreno-Loshuertos (Author), Mathieu Baritaud (Author), Laura Vela (Author), Kevin Garbin (Author), Delphine Garnier (Author), Christophe Lemaire (Author), Francina Langa-Vives (Author), Martine Cohen-Salmon (Author), Patricio Fernández-Silva (Author), Fabrice Chrétien (Author), Isabelle Migeotte (Author), Santos A. Susin (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Apoptosis-Inducing Factor (AIF) is a protein involved in mitochondrial electron transport chain assembly/stability and programmed cell death. The relevant role of this protein is underlined because mutations altering mitochondrial AIF properties result in acute pediatric mitochondriopath...