Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus

• Váldodahkkit: Laure Delavallée (Dahkki), Navrita Mathiah (Dahkki), Lauriane Cabon (Dahkki), Aurélien Mazeraud (Dahkki), Marie-Noelle Br (Dahkki), Leticia K. Lerner (Dahkki), Mariana Tannoury (Dahkki), Alexandre Prola (Dahkki), Raquel Moreno-Loshuertos (Dahkki), Mathieu Baritaud (Dahkki), Laura Vela (Dahkki), Kevin Garbin (Dahkki), Delphine Garnier (Dahkki), Christophe Lemaire (Dahkki), Francina Langa-Vives (Dahkki), Martine Cohen-Salmon (Dahkki), Patricio Fernández-Silva (Dahkki), Fabrice Chrétien (Dahkki), Isabelle Migeotte (Dahkki), Santos A. Susin (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2020-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objectives: Apoptosis-Inducing Factor (AIF) is a protein involved in mitochondrial electron transport chain assembly/stability and programmed cell death. The relevant role of this protein is underlined because mutations altering mitochondrial AIF properties result in acute pediatric mitochondriopath...