Sub-Acute Oral Toxicity of a Novel Derivative of Agomelatine in Rats in a Sex-Dependent Manner

• Main Authors: Qiushi Yang (Author), Xuelin Zhou (Author), Jingyi Li (Author), Yi Ma (Author), Li Lu (Author), Jie Xiong (Author), Pingxiang Xu (Author), Yuhang Li (Author), Yi Chen (Author), Wei Gu (Author), Ming Xue (Author), Zengliang Jin (Author), Xiaorong Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Agomelatine (AGO) is a new type of antidepressant with demonstrated antidepressant effects and a unique modulating circadian rhythm action. However, AGO has hepatotoxicity, which limits its clinical application. In order to develop new drugs that cause less liver injury than AGO, a series of derivat...