Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson's disease-like pathology

• Main Authors: Qianqian Cao (Author), Shilin Luo (Author), Wei Yao (Author), Youge Qu (Author), Nanbu Wang (Author), Jian Hong (Author), Shigeo Murayama (Author), Zhentao Zhang (Author), Jiaxu Chen (Author), Kenji Hashimoto (Author), Qi Qi (Author), Ji-chun Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain. LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn). Thus, strategies to reduce the expression of α-Syn offer promising therapeutic avenues for PD. DNA/RNA heteroduplex oligonu...