Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate.

Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate.

Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W. bancrofti and additional cases by the worms B. malayi and B. timori. Dihydrofolate reductase (DHFR) is an established target in the treatment of can...

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Main Authors: Keith Lange (Author), Kathleen M Frey (Author), Tyler Eck (Author), Cheryl A Janson (Author), Ueli Gubler (Author), Nina M Goodey (Author)
Format: Book
Published: Public Library of Science (PLoS), 2023-04-01T00:00:00Z.
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3rd Floor Main Library

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