Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance

• Main Authors: Shinichiro Hosaka (Author), Tetsuya Yamada (Author), Kei Takahashi (Author), Takashi Dan (Author), Keizo Kaneko (Author), Shinjiro Kodama (Author), Yoichiro Asai (Author), Yuichiro Munakata (Author), Akira Endo (Author), Hiroto Sugawara (Author), Yohei Kawana (Author), Junpei Yamamoto (Author), Tomohito Izumi (Author), Shojiro Sawada (Author), Junta Imai (Author), Toshio Miyata (Author), Hideki Katagiri (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leptin resistance is an important mechanism underlying the development and maintenance of obesity and is thus regarded as a promising target of obesity treatment. Plasminogen activator inhibitor 1 (PAI-1), a physiological inhibitor of tissue-type and urokinase-type plasminogen activators, is produce...