Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells

• Main Authors: Keizo Kohno (Author), Satomi Koya-Miyata (Author), Akira Harashima (Author), Takahiko Tsukuda (Author), Masataka Katakami (Author), Toshio Ariyasu (Author), Shimpei Ushio (Author), Kanso Iwaki (Author)
• Format: Book
• Published: BMC, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory...