CRISPR-based editing strategies to rectify EYA1 complex genomic rearrangement linked to haploinsufficiency

• Main Authors: Hwalin Yi (Author), Yejin Yun (Author), Won Hoon Choi (Author), Hye-Yeon Hwang (Author), Ju Hyuen Cha (Author), Heeyoung Seok (Author), Jae-Jin Song (Author), Jun Ho Lee (Author), Sang-Yeon Lee (Author), Daesik Kim (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pathogenic structure variations (SVs) are associated with various types of cancer and rare genetic diseases. Recent studies have used Cas9 nuclease with paired guide RNAs (gRNAs) to generate targeted chromosomal rearrangements, focusing on producing fusion proteins that cause cancer, whereas researc...