Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity

• Main Authors: Ilia A. Bolosov (Author), Pavel V. Panteleev (Author), Sergei V. Sychev (Author), Veronika A. Khokhlova (Author), Victoria N. Safronova (Author), Ilia Yu. Toropygin (Author), Tatiana I. Kombarova (Author), Olga V. Korobova (Author), Eugenia S. Pereskokova (Author), Alexander I. Borzilov (Author), Tatiana V. Ovchinnikova (Author), Sergey V. Balandin (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protegrin-1 (PG-1) is a cationic β-hairpin pore-forming antimicrobial peptide having a membranolytic mechanism of action. It possesses in vitro a potent antimicrobial activity against a panel of clinically relevant MDR ESKAPE pathogens. However, its extremely high hemolytic activity and cytotoxicity...