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Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity

Protegrin-1 (PG-1) is a cationic β-hairpin pore-forming antimicrobial peptide having a membranolytic mechanism of action. It possesses in vitro a potent antimicrobial activity against a panel of clinically relevant MDR ESKAPE pathogens. However, its extremely high hemolytic activity and cytotoxicity...

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Main Authors: Ilia A. Bolosov (Author), Pavel V. Panteleev (Author), Sergei V. Sychev (Author), Veronika A. Khokhlova (Author), Victoria N. Safronova (Author), Ilia Yu. Toropygin (Author), Tatiana I. Kombarova (Author), Olga V. Korobova (Author), Eugenia S. Pereskokova (Author), Alexander I. Borzilov (Author), Tatiana V. Ovchinnikova (Author), Sergey V. Balandin (Author)
Format: Book
Published: MDPI AG, 2023-07-01T00:00:00Z.
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