Current Development of siRNA Bioconjugates: From Research to the Clinic

• المؤلفون الرئيسيون: Ivan V. Chernikov (مؤلف), Valentin V. Vlassov (مؤلف), Elena L. Chernolovskaya (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to recognize a homologous mRNA sequence in the cell and induce its degradation. The main problems in the development of siRNA-based drugs for therapeutic use are the low efficiency of siRNA delivery to target cells and t...