Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines

• Main Authors: Kanyani Sangpheak (Author), Monika Mueller (Author), Nitchakan Darai (Author), Peter Wolschann (Author), Chonticha Suwattanasophon (Author), Ritbey Ruga (Author), Warinthon Chavasiri (Author), Supaporn Seetaha (Author), Kiattawee Choowongkomon (Author), Nawee Kungwan (Author), Chompoonut Rungnim (Author), Thanyada Rungrotmongkol (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted cancer therapy has become one of the high potential cancer treatments. Human topoisomerase II (hTopoII), which catalyzes the cleavage and rejoining of double-stranded DNA, is an important molecular target for the development of novel cancer therapeutics. In order to diversify the pharmacolo...